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雙特異性抗體研發(fā)進展

來源：藥物分析雜志 2019, Vol. 39 Issue (1): 78-85. DOI: 10.16155/j.0254-1793.2019.01.10

張峰 , 王開芹 , 王蘭

摘要：雙特異性抗體（bsAb）因可同時特異性結合2個不同抗原表位，拓展了治療性單克隆抗體的臨床應用范圍。制備bsAb需要對傳統(tǒng)的抗體結構進行改造，在此過程中衍生出了數十種結構，不同的結構具有不同的作用特點。本綜述就當前典型的bsAb結構及其原理進行介紹，對bsAb的作用原理進行分析，并對當前代表性的bsAb的研發(fā)階段進行了簡單總結。

關鍵詞：雙特異性抗體（bsAb）單克隆抗體抗體結構研發(fā) 進展

Development in bispecific antibody

ZHANG Feng, WANG Kai-qin, WANG Lan

Abstract: The clinical application of therapeutic monoclonal antibody has been extended by bispesific antibody (bsAb)due to their capacity of binding two different antigenic epitopes.Structure changing would be needed for the construction of bsAb.There are several tens of bsAb structures developed, the specific action characteristics of which are related with their unique bsAb structure.In this review, typical structures and acting principles of bsAb were introduced, the action principle of bsAb was analyzed, and the development stages of representative bsAb were briefly summarized.

Key words: bispecific antibody(bsAb) monoclonal antibody antibody structure research development

雙特異性抗體研發(fā)進展

藥物分析雜志 2019, Vol. 39 Issue (1): 78-85. DOI: 10.16155/j.0254-1793.2019.01.10

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